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表达MMP13和表达COL11A1的癌症相关纤维细胞:食道状细胞癌进展和预后指标的关键驱动因素

Shu Kato¹, Yuki Kato¹, Makoto Kodama²

¹Department of Human Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Laboratory investigation; a journal of technical methods and pathology

|September 26, 2025

概括

与癌症相关的纤维细胞 (CAFs) 驱动食道癌症的进展. 研究人员确定了三种肌纤维细胞CAF (myCAF) 亚型,其中MMP13+和COL11A1+ myCAF与食道状细胞癌的不良预后和转移有关.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
免疫学免疫学免疫学

背景情况:

癌症相关纤维细胞 (CAFs) 是瘤微环境中的关键参与者,影响癌症的进展和转移.
虽然CAF与食道状细胞癌 (ESCC) 有关,但它们在病理阶段的具体作用尚不清楚.

研究的目的:

在ESCC的瘤微环境中识别和描述不同的CAF亚型.
研究CAF特定亚型与临床病理特征,免疫细胞透和患者预后之间的关联.

主要方法:

使用单细胞RNA测序来识别和分类CAF.
用RNA in situ杂交来验证患者标本中CAF亚型的存在.
进行了相关性分析,以将CAF亚型与病理特征和预后联系起来.

主要成果:

确定了三种肌纤维细胞CAF (myCAF) 群:MMP13+,COL11A1+和SFRP4+ myCAFs,在晚期患病率增加.
不同的免疫细胞种群,包括M2巨细胞和特定的T细胞子集,与这些myCAF集群有关.
MMP13+ myCAF与差异化瘤相关,而COL11A1+ myCAF与淋巴结转移有关,两者都与预后不佳有关.

结论:

特定的myCAF亚型 (MMP13+和COL11A1+) 是ESCC中的显著预后标志物.
这些发现突显了针对性治疗和基于CAF亚型的患者分层在ESCC治疗策略中的潜力.

关键词:

与癌症相关的纤维细胞.面向案例的单细胞RNA测序.食管状细胞癌的癌症细胞外矩阵是细胞外矩阵.一个单细胞RNA测序.瘤微环境是一个微环境.

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