在血液透析患者中治疗前列腺癌的碳离子放射治疗
Hikaru Imafuku1,2, Kotaro Terashima3, Kaori Fukunishi1
1Ion Beam Therapy Center, SAGA-HIMAT Foundation, Saga, Japan.
Anticancer research
|September 26, 2025
概括
碳离子辐射疗法 (CIRT) 对接受血液透析的前列腺癌患者是安全的,具有有限的毒性. 这表明CIRT对于这个特定的患者群体来说是一个可行的治疗选择.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 碳离子辐射疗法 (CIRT) 是为癌症治疗而建立的.
- 在接受血液透析的前列腺癌患者中,其安全性和有效性仍未得到充分研究.
- 血液透析患者在癌症治疗毒性评估方面存在独特的挑战.
研究的目的:
- 评估CIRT对血液透析患者前列腺癌的毒性和安全性.
- 确定CIRT在这个特定人群中的临床结果和副作用.
主要方法:
- 用CIRT治疗的13名前列腺癌血液透析患者的回顾性分析.
- 通过被动散射或扫描技术 (51.6 Gy (RBE) 分为12个分数) 传递的CIRT.
- 使用常用术语标准对不良事件 (CTCAE) 版本5.0.0进行毒性评估.
主要成果:
- 急性泌尿生殖系统 (GU) 毒性:3名患者的1级,2名患者的2级.
- 晚期胃肠道毒性:在1名患者中,1级.
- 没有观察到3级或更高的毒性;9名患者实现了无复发的生存.
结论:
- 在血液透析中,CIRT可以安全地给前列腺癌患者使用.
- 观察到的毒性在这个人群中处于可接受的范围内.
- 对于前列腺癌的血液透析患者来说,CIRT显示出作为安全有效的治疗选择的潜力.
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