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在帕金森病中,VPS13C异构性功能丧失作为对利沃多巴治疗次优反应的修饰剂

Lorenzo Malfer1, Capucine Piat1, Eduardo E Benarroch1

  • 1Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Parkinsonism & related disorders
|September 26, 2025
PubMed
概括

VPS13C基因中的致病变体可能会增加早期发病的帕金森病 (EOPD) 风险,并影响非运动症状. 这些遗传变异可能导致EOPD患者对利沃多巴治疗的亚优反应.

关键词:
早期发病的帕金森病.莱沃多巴的反应性非运动症状 非运动症状在PARK23中,我们可以看到.这是一个VPS13C.

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