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三甘油与高血糖-C的比率与认知障碍之间的关联:基于人口的纵向分析和孟德尔随机化研究

Yucheng Huang¹, Lijia Zheng², Meng-Meng Lyu³

¹Department of Biostatistics (Y.H.), Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

|September 26, 2025

概括

高甘油与高密度脂蛋白胆固醇 (TG/HDL-C) 的比率与老年人的认知能力下降有关. 管理脂质代谢可能有助于预防认知障碍,这表明TG/HDL-C是关键可修改的危险因素.

科学领域:

老年学是一门学科.
心血管健康心血管健康
神经科学是一个神经科学.

背景情况:

甘油三和高密度脂蛋白胆固醇 (TG/HDL-C) 的比例是新兴的代谢健康标志物.
认知障碍是全球老年人口日益关注的问题.
了解认知能力下降的可修改风险因素对于公共卫生至关重要.

研究的目的:

调查TG/HDL-C比率与老年人认知障碍之间的纵向关联.
使用孟德尔随机化 (MR) 评估TG/HDL-C比率与认知衰退之间的潜在因果关系.

主要方法:

基于人口的纵向分析,使用来自欧洲健康,老龄化和退休调查 (SHARE) 波6-8的数据.
层次回归和混合线性效应模型被用于纵向分析.
两个样本的孟德尔随机化 (MR) 使用全基因组关联研究 (GWAS) 总结数据.

主要成果:

较高的TG/HDL-C比率与较低的总认知得分和特定的认知领域显著相关,包括即时回忆,延迟回忆,口头流利和计算能力.
纵向分析表明,在4年的时间里,高TG/HDL-C四分位数内的老年人患有认知障碍的风险增加.
对MR的分析提供了证据,支持TG/HDL-C升高与认知能力下降之间的因果关系.

结论:

较高的TG/HDL-C比率表明,在老年人中,与认知能力下降具有显著的纵向关联.
管理脂质代谢,特别是关注TG/HDL-C比率,可能是减轻认知障碍的可行策略.
在老年人群中,TG/HDL-C比率代表了潜在的可修改的认知健康风险因素.

关键词:

分享分享分享分享在TG/HDL-C的比率.认知障碍是一种认知障碍.门德尔的随机化是门德尔的随机化多层次分析的多层次分析.

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