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Updated: Jan 16, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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超紧的转录降解剂的新设计是通过对基质特异性毒素和Cas6-CBS系统的工程设计

Pin-Ru Chen1, Pei-Pei Qin1, Ya-Nan Wang1

  • 1Institute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, China.

Nature communications
|September 26, 2025
PubMed
概括

研究人员开发了STAR,这是一种使用小毒素蛋白和dCas6.6的新型RNA降解系统. 这种紧的系统有效地降解细胞中的点RNA,为CRISPR和RNAi等现有技术提供了更安全的替代方案.

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