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Updated: Jan 16, 2026

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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一个域互换的CaMKII构造促进了链接介导的全调节

Bao V Nguyen1,2,3, Can Özden1,3, Kairong Dong1,4

  • 1Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA.

Nature communications
|September 26, 2025
PubMed
概括

在Ca2+/卡尔莫杜林依赖蛋白激酶II (CaMKII) 链接区的充电残留物控制了Ca2+的敏感性. 一个结构模型揭示了链接电荷定位如何影响CaMKII自身抑制,影响细胞中的Ca2+信号传递.

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