味觉性丘脑神经元介导厌恶行为
Feng Cao1,2,3, Sekun Park4,5, Jordan L Pauli4,5
1Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. feng.cao@wwu.edu.
Nature communications
|September 26, 2025
概括
味觉丘脑 (VPMpc) 传递味觉信号,并调解厌恶行为. 这项研究揭示了表达胆囊托基宁和片受体的VPMpc神经元对于处理有害刺激和恐惧记忆至关重要.
科学领域:
- 神经科学是一个神经科学.
- 感官系统 感官系统
- 行为科学 行为科学
背景情况:
- 腹腔后中核 (VPMpc) 的细胞部分,或味觉,传统上传递味觉信息.
- 以前的研究主要集中在VPMpc在向味觉皮层传递味觉信号中的作用上.
研究的目的:
- 为了研究VPMpc神经元在味觉感知之外的作用.
- 为了确定VPMpc是否调解厌恶行为和恐惧记忆.
主要方法:
- 在小鼠单个神经元的体内成像.
- 记录神经元活动以响应有害刺激和恐惧记忆.
- 化学遗传和光遗传操纵VPMpc神经活动.
主要成果:
- 表达胆囊托基宁和片受体的VPMpc神经元对有害刺激和恐惧记忆做出反应.
- 这些VPMpc神经元的激活增强了对厌恶刺激的反应.
- 沉默这些神经元减弱了厌恶行为.
结论:
- VPMpc在调解厌恶行为方面发挥着重要作用,而不仅仅是味觉.
- VPMpc神经元向岛内皮层和侧面杏仁核传递厌恶和威胁信号.
- 这扩大了口味丘脑在威胁处理中的已知功能.
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