大西洋可以改善代谢功能障碍相关的脂肪肝病患者的氧化状态
Roghayeh Mostafaei1,2,3, Seyed Mostafa Nachvak4,5, Amir Saber2,3
1Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Scientific reports
|September 26, 2025
概括
皮斯塔西亚亚特兰大在患有代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的患者中显著降低了脂肪肝等级和马隆迪甲水平. 这表明对MAFLD中氧化应激管理的潜在益处.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 氧化压力研究研究 氧化压力研究
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个全球性的健康问题.
- 氧化应激在MAFLD的发病和进展中起着至关重要的作用.
研究的目的:
- 为了研究Pistacia atlantica Sub.的疗效. 库尔迪卡在改善MAFLD患者的氧化状态.
- 评估P. atlantica乳糖对脂肪肝等级和氧化应激标志物的影响.
主要方法:
- 这是一项双盲随机临床试验,涉及50名MAFLD患者.
- 参与者在两个月内接受了含500毫克P. atlantica口香糖的糖或安慰剂.
- 评估了人体测量措施,血清氧化标记 (TOS,TAC,MDA) 和在基线和干预结束时的身体活动.
主要成果:
- 在P. atlantica牙组 (p=0.03) 中观察到脂肪肝等级的显著降低.
- 与安慰剂 (p=0.025) 相比,在P. atlantica口香糖组 (p=0.002) 中,马隆迪甲 (MDA) 水平显著下降.
- 在P. atlantica口香糖组 (p<0.001) 观察到显著的体重减轻.
结论:
- 大西洋豆 (Pistacia atlantica) 亚 在MAFLD患者中,库尔迪卡显示出改善特定氧化应激标志物的潜力,特别是脂质过氧化 (MDA).
- 这些发现表明对MAFLD进展有有益影响,需要进一步调查.
- 建议采用更大的样本大小,更长的持续时间和剂量反应研究进行全面评估.
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