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Updated: Jan 16, 2026

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CYP27B1 p.R389H 突变对蛋白质稳定性和功能的影响:对多发性硬化症病原体的影响

Rizwan Ahmed Kiani1, Feroza Hamid Wattoo2, Muhammad Umer Khan3

  • 1PMAS University of Arid Agriculture, Rawalpindi, Punjab, Pakistan.

Scientific reports
|September 26, 2025
PubMed
概括

CYP27B1 p.R389H突变可能会破坏维生素D的新陈代谢和免疫功能,可能导致多发性硬化症 (MS) 的发展. 计算分析显示,这种遗传变异可能会损害蛋白质的稳定性和功能.

关键词:
在CYP27B1中.分子模拟分子模拟多发性硬化症是多发性硬化症.突变突变是一种突变.维生素D 维生素D是一种维生素.

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