白质神经基质与遗传风险相关的酒精依赖及其在病态奖励过程中的作用
Fei Wu1, Guowei Wu2, Ping Dong1
1NHC Key Laboratory of Mental Health (Peking University), Peking University Sixth Hospital, Peking University Institute of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, 100191, China.
Scientific reports
|September 26, 2025
概括
患有酒精依赖和家庭有酒精使用障碍史的个人在海马体中表现出明显的白质异常. 这些大脑变化与病态的渴望有关,这表明对酒精依赖的遗传影响.
科学领域:
- 神经成像是一种神经成像.
- 遗传学 是一个遗传学.
- 药物成科学 药物成科学
背景情况:
- 酒精使用障碍 (AUD) 与白质 (WM) 和网络连接体异常有关.
- 在酒精依赖 (AD) 中的神经成像特征与家族史 (FH) 的AUD及其与渴望的联系尚未得到充分理解.
- 了解AUD遗传性是识别遗传倾向和预防的关键.
研究的目的:
- 为了调查神经成像对酒精依赖 (AD) 患者的差异,有或没有AUD的家族史.
- 探索白质异常,遗传风险和AD病理渴望之间的关系.
- 确定与家族史和渴望相关的奖励系统的特定拓性质.
主要方法:
- 招募了51名AD患者 (21名FHP,30名FHN) 和25名健康对照 (HC).
- 状电路和奖励系统拓学的比较分数异构性 (FA) 和平均扩散性 (MD).
- 在FHP和FHN组之间控制了酒精使用的持续时间和严重程度.
主要成果:
- 与健康对照组 (HC) 相比,患有AD家族史阳性 (FHP) 的AD患者表现出异常的海马体拓.
- 即使在控制共变量后,与FHN患者相比,FHP患者也表现出乱的海马体拓 (较低的节点间距,节点度;较高的最短路径).
- 右海马节点的拓特性与阿兹海默症患者自我报告的渴望有显著的相关性.
结论:
- 在阿尔茨海默病中,白质异常是明显的,特别是在具有高遗传风险 (FHP) 的个体中.
- 右海马的拓学属性的破坏与阿尔茨海默病的渴望水平有关.
- 研究结果强调了遗传倾向在与阿尔茨海默病相关的神经变化和渴望中所起的作用.
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