差异化甲状腺癌术后复发的危险因素:一项回顾性研究
Shuo Han1, Yanqing Yang2, Wufuer Yimaer1
1Department of Vascular and Thyroid Surgery, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, 830000, China.
Scientific reports
|September 27, 2025
概括
手术后差异化甲状腺癌 (DTC) 的复发与男性性别,较大的瘤,多焦点性疾病,淋巴结转移和BRAF V600E突变有关. 双边甲状腺叶切除可能会降低DTC复发风险.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 遗传学 遗传学 是一个
背景情况:
- 差异化甲状腺癌 (DTC) 复发是一个重大的临床挑战.
- 识别风险因素对于个性化治疗和改善患者治疗结果至关重要.
研究的目的:
- 确定DTC术后复发的独立风险因素.
- 提供临床指导,以尽量减少DTC患者的复发风险.
主要方法:
- 对1118名接受手术的DTC患者的回顾性分析.
- 进行了单变量和考克斯多变量回归分析.
- 随访时间为36至60个月,以评估复发情况.
主要成果:
- 男性性别,较大的瘤大小,多焦点瘤,中心和侧淋巴结转移,以及BRAF V600E突变是复发的显著风险因素 (P <0.05).
- 双边甲状腺叶切除出现了作为一个重要的保护因素,防止复发 (P <0.05).
- 在1118名患者中,有46名患者在随访期间出现了复发.
结论:
- 男性性别,瘤特征,淋巴结参与和特定基因突变是DTC复发的关键预测因素.
- 像双边甲状腺叶切除等手术策略可能在预防复发方面发挥作用.
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