在患有多发性硬化症的患者中,睡眠质量的纵向变化及其预测因素
Habin Yun1, Dayoung Seo1,2, Yumin Jin1
1University of Ulsan College of Medicine, Seoul, 05505, South Korea.
Scientific reports
|September 27, 2025
概括
睡眠质量差在多发性硬化症 (MS) 患者中很普遍,并且与生活质量降低有关. 抑郁症和视觉功能障碍的严重程度预示着持续的睡眠问题,突显了在MS护理中需要有针对性的干预措施.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 生活质量研究 研究 生命质量研究
背景情况:
- 患有多发性硬化症 (PwMS) 的患者经常出现睡眠障碍.
- 在PwMS中影响睡眠的纵向模式和临床因素尚不清楚.
- 了解这些因素对于改善患者的治疗结果和生活质量至关重要.
研究的目的:
- 在PwMS中评估睡眠质量.
- 研究睡眠质量与生活质量之间的关联.
- 评估MS中睡眠障碍的长期轨迹和临床预测因素.
主要方法:
- 对118名多发性硬化症患者 (最近没有复发) 的前性队列研究.
- 在基线和6-12个月使用匹兹堡睡眠质量指数 (PSQI) 评估睡眠质量.
- 分析了包括光学功能系统得分和抑郁症在内的临床因素与PSQI得分的关联.
主要成果:
- 54%的PwMS在基线时睡眠不佳 (PSQI>5),在随访时患病率相似 (53%).
- 睡眠质量差独立与生活质量低下相关.
- 基线光学功能系统得分和抑郁症独立预测了当前和未来的PSQI得分.
结论:
- 睡眠质量差是多发性硬化症患者常见和持续的问题.
- 抑郁症和视觉功能障碍的严重程度是MS患者睡眠障碍的重要预测因素.
- 有针对性的睡眠管理策略是PwMS综合护理的重要组成部分.
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