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双相 (状) 乳头性细胞癌:在PRCC谱中是一个独特的分子和形态亚型

Zhichun Lu¹, Yan Zhou², Wei Fan²

¹Department of Pathology & Laboratory Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, 670 Albany St., Boston, MA, 02118, USA. zhichun.lu@bmc.org.

Virchows Archiv : an international journal of pathology

|September 27, 2025

概括

双相 (状) 乳头性细胞癌 (BPRCC) 是一种独特的癌亚型. 分子分析揭示了独特的NOTCH,MAPK和DNA修复途径的改变,支持其作为一个独立实体的分类.

科学领域:

在瘤学瘤学.
脏病理学脏病理学
分子诊断学分子诊断

背景情况:

双相 (状) 乳头性细胞癌 (BPRCC) 是一种罕见的细胞癌变体.
它独特的临床病理学和分子特征需要进一步探索.

研究的目的:

描述BPRCC的组织学,免疫类型,分子和临床特征.
为了确定BPRCC是否代表了斑纹性细胞癌的独特亚型.

主要方法:

对十例BPRCC病例的组织学和免疫类型分析.
在染色体异常的情况下进行光在位杂交 (FISH).
下一代测序 (NGS) 用于针对基因突变和放大.

主要成果:

所有十个BPRCC瘤都表现出双相形态,并被分为pT1.1.
免疫组织化学显示PAX8,CK7,AMACR和Claudin4的扩散阳性,细胞群之间的表达差异.
在所有病例中,FISH证实了三发症7和17. 在90%的病例中,NGS发现了NOTCH1突变,30%的MET改变,以及DDR和染色体重塑基因的改变.

结论:

BPRCC是一种独特的状细胞癌亚型,其特征是双相形态和特定的免疫表型标记.
对于NOTCH,MAPK和DNA损伤反应 (DDR) 途径的改变,BPRCC的分子概况得到了丰富.
在研究的队列中,BPRCC显示了有利的临床结果,没有观察到疾病进展或与癌症相关的死亡.

关键词:

双相性双相性双相性远距离的绕的管道.状细胞癌是状细胞癌.靠近的绕的管道.斯克瓦莫伊德 (squamoid) 是一种类型的虫.

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