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胰腺炎在儿童IBD诊断之前:一项回顾性观察性研究
Lorenzo D'Antonio1,2, Valerio Balassone1, Federico Alghisi3
1Gastroenterology, Endoscopy and Surgery Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Children (Basel, Switzerland)
|September 27, 2025
概括
胰腺炎可以在儿童的炎症性肠病 (IBD) 诊断之前,作为早期迹象. 在儿科胰腺炎中便calprotectin水平升高需要考虑IBD.
科学领域:
- 胃肠病学 胃肠病学
- 儿科医学 儿科医学
- 炎症性肠道疾病研究研究
背景情况:
- 胰腺干扰在炎症性肠病 (IBD) 中很常见,包括急性胰腺炎 (AP) 等疾病.
- 胰腺炎作为IBD的前体的作用未被充分认识到,很少报告,特别是在儿科病例中.
研究的目的:
- 调查儿科患者在IBD诊断之前急性胰腺炎 (AP) 的发生率,原因,严重程度和复发情况.
- 加强早期识别和诊断IBD在儿童呈现胰腺炎的策略.
主要方法:
- 在IBD之前被诊断患有胰腺炎的儿科患者的回顾性观察研究.
- 数据收集包括人口统计,临床表现,实验室发现,成像,便calprotectin和内镜结果.
- 对312名儿科IBD患者的分析,确定那些先前患有胰腺炎的患者.
主要成果:
- 在312名儿科IBD患者中,11名 (3.5%) 在IBD诊断之前经历了胰腺炎.
- 所有先前患有胰腺炎的患者都表现出便中calprotectin水平升高.
- 在所有病例中,内镜证实IBD (克罗恩氏病或性结肠炎),从胰腺炎发作到IBD诊断的中位时间为77周.
结论:
- 胰腺炎可以作为儿童IBD诊断前的早期肠外表现,类似于成人发现.
- 应将IBD纳入儿科胰腺炎的差异诊断,特别是在异常病例中.
- 建议在儿科胰腺炎治疗和随访时进行便calprotectin测试,以帮助早期发现IBD.
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