婴儿恶性固体瘤的结果:一个单一中心的经验
Burcu Tufan Taş1, Nurşah Eker1
1Department of Pediatric Hematology and Oncology, Pendik Training and Research Hospital, Marmara University, Istanbul 34899, Turkey.
Children (Basel, Switzerland)
|September 27, 2025
概括
婴儿恶性固体瘤很少见,并且差异很大. 大脑瘤的结果较差,而腹内瘤的情况更好,这凸显了针对婴儿癌症治疗的需要.
科学领域:
- 儿科瘤学 儿科瘤学
- 婴儿癌症研究 婴儿癌症研究
- 瘤生物学 瘤生物学
背景情况:
- 婴儿 (<1岁) 的恶性固体瘤很少见,但由于发育因素,与较大的儿童不同.
- 这些瘤表现出独特的生物行为,治疗反应和预后.
- 与年龄相关的治疗限制会影响这个弱势群体的治疗结果.
研究的目的:
- 分析被诊断患有恶性固体瘤的婴儿的临床特征,治疗模式和生存结果.
- 确定影响这一群体生存的预后因素.
- 为婴儿癌症提供特定年龄,风险适应的治疗策略.
主要方法:
- 追溯分析88名患有恶性固体瘤的婴儿,年龄在12个月之前被诊断出.
- 收集的数据包括人口统计,临床表现,病理学和治疗细节.
- 使用卡普兰-梅尔分析的整体存活率 (OS),通过考克斯回归评估预后因素.
主要成果:
- 最常见的部位是腹内部 (64.7%) 和大脑 (20.5%).
- 神经母细胞瘤是主要的诊断 (30.7%),其中29.6%显示自发回归.
- 大脑瘤 (特别是非典型的甲状腺瘤 - - ATRT) 的死亡率更高 (HR 4.32),而腹内瘤的生存率更高 (HR 0.31). 五年后的生存率为78.3%.
结论:
- 婴儿恶性固体瘤在临床上是异质的,结果各不相同.
- 神经母细胞瘤和软组织肉瘤显示出良好的结果,但脑瘤,特别是ATRT,仍然具有挑战性.
- 开发特定于年龄的,适应风险的治疗方法和改善早期检测对于更好的生存和减少后果至关重要.
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