含的纳米粒在氧化环境下延缓BMSC的细胞衰老,并保持其再生能力
Zirui He1,2, Fangru Xie2, Chuanhao Sun3
1The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Bioengineering (Basel, Switzerland)
|September 27, 2025
概括
研究人员开发了含有的纳米粒来对抗干细胞中的氧化应激. 这些纳米微粒有效地清除反应性氧物种 (ROS),延迟细胞衰老,并保留衰老组织中的干细胞功能.
科学领域:
- 生物医学工程 生物医学工程
- 干细胞生物学 干细胞生物学
- 纳米技术纳米技术
背景情况:
- 细胞衰老和干细胞功能下降有助于衰老.
- 由活性氧物种 (ROS) 驱动的氧化应激是干细胞衰老的主要原因.
- 降低再生能力和抗病能力是组织衰老的标志.
研究的目的:
- 开发一种新的治疗策略,以缓解由氧化应激引起的干细胞衰老.
- 为了研究含有 (Se) 的纳米在保护骨髓介质干细胞 (BMSCs) 中的ROS响应性纳米的有效性.
主要方法:
- 用BMSC作为模型系统来研究细胞衰老.
- 含有ROS响应的 (Se) 的纳米微粒被合成并针对Se含量进行了优化.
- 最佳纳米细胞配方 (8%Se,15μg/mL) 在氧化应激下测试了其吸收细胞内ROS和调节BMSC中的衰老标志物的能力.
主要成果:
- 优化的纳米细胞显著降低了暴露于氧化应激的BMSC中的ROS水平.
- 使用纳米菌的治疗有效地延迟了细胞衰老标志物.
- 在纳米菌治疗后,BMSCs的骨质分化潜力保持不变.
结论:
- 含有的纳米微粒代表了一种有前途的方法来抵消氧化应激诱导的干细胞衰老.
- 这一策略可以帮助维持干细胞的功能,并有可能改善衰老组织的再生能力.
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