精确控制的生物肺模拟器用于动态呼吸模拟
Rong-Heng Zhao1, Shuai Ren1, Yan Shi2
1School of Automation, Beijing Institute of Technology, Beijing 100081, China.
Bioengineering (Basel, Switzerland)
|September 27, 2025
概括
这项研究引入了一种新型的双室肺模拟器,能够使用主动和被动模式进行先进的呼吸器测试和呼吸研究. 它的精确控制准确地模仿复杂的呼吸模式和ARDS和COPD等病理状况.
科学领域:
- 生物医学工程 生物医学工程
- 呼吸系统生理学 呼吸系统生理学
- 控制系统 控制系统
背景情况:
- 机械通风对于严重的呼吸道疾病至关重要.
- 现有的肺部模拟器缺乏现实的动态控制和病理模拟能力.
- 高保真模拟器对于通风器测试,培训和研究至关重要.
研究的目的:
- 开发一款多功能双室肺模拟器,可在主动和被动模式下运行.
- 为了能够准确地复制复杂的呼吸模式和病理状况.
- 加强呼吸器测试,临床培训和呼吸系统研究.
主要方法:
- 实现一个滑动模式控制器与线性扩展状态观察器.
- 开发一个双室系统,用于主动和被动模式的操作.
- 参数调整以模拟生理和病理呼吸机制 (ARDS,COPD).
主要成果:
- 复制复杂的呼吸模式的准确复制,绝对流量误差在±3L/分钟内.
- 响应时间低于200ms,确保快速可靠的性能.
- 被动模式提供肺部符合性 (30-100毫升/厘米H2O) 和气道阻力 (2.01-14.67厘米H2O/厘米L/秒) 的连续调节,符合性偏差为±5%.
结论:
- 开发的双室肺模拟器在主动和被动两种模式下都能精确控制呼吸机制.
- 它有效地模拟生理和病理呼吸条件,推进呼吸器测试和研究.
- 该系统的适应性和性能使其适合评估通风器的有效性和研究呼吸护理中的人机相互作用.
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