鱼类中的肠道微生物群和宿主防御之间的交叉声
Xiao-Zheng Yu1, Yang Yu2, Zi-Yan Liu2
1Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China.
Biology
|September 27, 2025
概括
主体防御 (HDP) 和肠道微生物群的相互作用是可持续水产养殖的关键. 这种相互作用增强了水生动物的健康,免疫力和生长,同时减少了抗生素的使用.
科学领域:
- 水产养殖免疫学 水产养殖免疫学
- 微生物组研究的研究.
- 这是天生的免疫力.
背景情况:
- 肠道微生物群和宿主防御 (HDPs) 极大地影响水生动物的健康.
- HDPs是多功能免疫分子,可以对抗病原体并调节肠道微生物群落.
- 来自微生物群的信号通过宿主免疫路径 (如托尔类受体 (TLRs)) 调节HDP表达.
研究的目的:
- 审查肠道微生物群和水产养殖中的HDP之间的双向相互作用.
- 突出这些相互作用对水生动物健康,疾病抵抗力和生长的作用.
- 讨论实际应用,挑战和未来的研究方向.
主要方法:
- 文献综述综合了当前关于微生物群和HDP交叉通话的研究.
- 分析HDP在病原体中和微生物社区调节中的功能.
- 检查微生物对HDP表达和宿主免疫反应的调节.
主要成果:
- HDPs通过中和病原体和促进有益细菌来增强疾病抵抗力.
- 肠道微生物群调节HDP的产生,放大了先天的防御能力.
- 这种交叉支营养吸收,肠道屏障完整性和免疫平衡.
- 富含HDP的料和益生菌协同作用在提高生产率和降低死亡率方面显示出希望.
结论:
- 微生物群-HDP轴对可持续水产养殖和减少抗生素至关重要.
- 挑战包括HDP的不稳定性和网络的复杂性,需要创新的解决方案.
- 未来的研究应该集中在无抗生素水产养殖的工程微生物,多组体和组合疗法上.
相关概念视频
01:26Defense Mechanism Against Infection
9.2K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.2K
01:29Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
1.1K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.1K
01:05Physiology of Enteric Nervous System and Gut Health
875
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
875
01:28Gene Regulation in Microbial Communities: Quorum Sensing
524
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
524