在非霍奇金B细胞淋巴瘤中肠道微生物群失生症和饮食干预:对治疗反应的影响
Santino Caserta1, Maria Eugenia Alvaro1, Giuseppa Penna1
1Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, via Consolare Valeria, 98125 Messina, Italy.
肠道微生物群影响非霍奇金B细胞淋巴瘤的发展和治疗反应. 恢复微生物平衡可能会改善淋巴瘤患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 非霍奇金B细胞淋巴瘤是各种淋巴状癌症.
- 肠道微生物群显著影响癌症的发展和治疗的有效性.
- 微生物失衡 (失生症) 即使在疾病的早期阶段也存在.
研究的目的:
- 探索肠道微生物群在非霍奇金B细胞淋巴瘤中的作用.
- 研究微生物失生症如何影响治疗结果.
- 确定潜在的基于微生物组的治疗策略.
主要方法:
- 审查关于肠道微生物群和淋巴瘤的现有证据.
- 分析了与治疗疗效和毒性相关的研究,分析了与治疗疗效和毒性有关的研究.
- 对调节微生物组的潜在干预措施的审查.
主要成果:
- 肠道疾病与化学免疫疗法和CAR T细胞治疗的反应较差有关.
- 抗生素的使用加剧了失生症和治疗的负面结果.
- 像Faecalibacterium prausnitzii这样的特定细菌可能会提供保护作用.
结论:
- 肠道微生物组是非霍奇金B细胞淋巴瘤的关键因素.
- 有针对性的干预措施,如益生菌和饮食改变,显示出有希望的结果.
- 需要进一步的研究来开发个性化微生物组疗法.
更多相关视频
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
08:14A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
What is Monogastric Digestion?
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Fungal Phylum Microsporidia
