天然提取物的抗菌活性对抗阴道殖民性甲素耐药黄金葡萄球菌 临床分离物
José Avendaño-Ortiz1,2, Alba Tribaldo1, Luna Ballestero1
1Department of Microbiology, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain.
Biomedicines
|September 27, 2025
概括
葡萄,和大等天然提取物在防止MRSA在血管内导管 (ICs) 上的殖民方面表现有前途. прополис提取物也表现出杀菌作用,为对抗耐药细菌提供了潜在的替代方案.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 传染性疾病 传染性疾病
背景情况:
- 血管内导管 (ICs) 容易受到细菌殖民,导致血液感染.
- 频繁的IC更换会引起患者的不适,并导致大量的医疗保健费用.
- 甲素耐药黄金葡萄球菌 (MRSA) 在临床环境中构成越来越大的威胁.
研究的目的:
- 评估天然提取物在防止ICs上MRSA殖民化的有效性.
- 为了确定具有对MRSA的细菌静止和杀菌性质的天然化合物.
- 探索这些提取物作为IC涂料的潜在应用.
主要方法:
- 测试了来自IC的36个临床MRSA分离物.
- 评估了大,葡萄和的提取物.
- 使用汁微稀释和复苏氨酸试验确定最小抑制度 (MIC) 和最小杀菌度 (MBC).
主要成果:
- 所有测试的天然提取物都表现出对MRSA的细菌静止活性.
- 葡萄提取物显示MIC90 (3.125毫克/毫升) 最低,其次是和大提取物.
- прополис 提取物显示出杀菌活性 (MBC = 25 mg/mL).
结论:
- 自然提取物显示出抑制IC上的MRSA的显著潜力.
- 蜂提取物表现出细菌静止和杀菌作用.
- 这些发现表明天然提取物是IC涂层的可行替代品,可以预防多药耐药性感染.
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