与代谢功能障碍相关的脂肪性肝病作为慢性病的危险因素:叙述性综述
Marcelo do Rego Maciel Souto Maior1, Nathália de Lacerda Interaminense Ribeiro2, Hannah Vicentini Vitoriano Silva2
1Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Pernambuco, Recife CEP 50670-901, Brazil.
Biomedicines
|September 27, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与慢性病 (CKD) 有关. 存在共同的风险因素,但直接的因果关系尚不清楚,因此需要对MASLD进行进一步的研究.
科学领域:
- 肝病学和病学 肝病学和病学
- 代谢和内分泌疾病 代谢和内分泌疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是全球最常见的慢性肝病.
- MASLD与慢性病 (CKD) 等肝外疾病独立相关,严重的形式带来更高的风险.
- 共同的心脏代谢风险因素 (肥胖,高血压,糖尿病) 使得在MASLD和CKD之间建立直接因果关系变得复杂.
研究的目的:
- 审查MASLD和CKD之间共享的风险因素.
- 探索MASLD对脏健康的潜在直接致病机制.
- 识别文献上的差距,并建议未来的研究方向.
主要方法:
- 文献综述和观察性研究的综合.
- 分析共享的风险因素和潜在的病理生理路径.
- 确定关于命名,儿科群体,MetALD和共同治疗的研究缺口.
主要成果:
- MASLD和CKD有许多心脏代谢风险因素,这使得直接因果关系难以证明.
- 潜在的MASLD驱动机制包括内分泌,血液动力,免疫和氧化应激途径.
- 在了解MASLD对CKD的影响方面存在重大差距,特别是在特定人群和联合酒精摄入场景中.
结论:
- MASLD与CKD有很强的关联,但确切的因果证据受到混因素和研究异质性的限制.
- 进一步的研究对于阐明直接的病原性联系和为综合管理策略提供信息至关重要.
- 解决研究缺陷对于预防或减轻MASLD患者功能障碍至关重要.
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