用复合人体生长激素治疗生长激素缺乏症儿童的营养咨询:生长反应参数分析
Joanna Budzulak1, Katarzyna Anna Majewska1, Andrzej Kędzia1
1Department of Pediatric Diabetes, Auxology and Obesity, Poznan University of Medical Sciences, 60-572 Poznan, Poland.
Biomedicines
|September 27, 2025
概括
饮食咨询并没有显著改善增长激素缺乏症 (GHD) 的儿童的生长,这些儿童接受了复合人体生长激素 (rhGH) 治疗. 在这项研究中,营养支持并没有提高身高标准偏差得分或身高速度.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 营养 营养 营养 营养 营养
背景情况:
- 发育不良是儿童生长激素缺乏症 (GHD) 的主要症状.
- 重组人体生长激素 (rhGH) 疗法是GHD的标准治疗方法.
- 营养状况可能会影响rhGH治疗的疗效,特别是在营养不良的儿童中.
研究的目的:
- 评估专业饮食咨询对接受rhGH治疗的青春期前儿童GHD生长反应的影响.
- 为了比较接受营养咨询的GHD儿童与没有接受营养咨询的儿童之间的生长参数.
主要方法:
- 一个研究小组包括29名患有GHD的青春期前儿童,他们在一年内与rhGH治疗一起接受了个性化饮食咨询.
- 一组47名患有GHD的青春期前儿童接受了无需饮食咨询的rhGH治疗.
- 增长反应参数,包括高度标准偏差得分 (ΔhSDS) 和高度速度 (HV),在两年内进行了评估.
主要成果:
- 与对照组相比,研究小组在两年的rhGH治疗中显示出略高的平均HV和ΔhSDS.
- 这些观察到的群体之间的生长参数差异没有达到统计学意义.
- 在整个研究期间,身体质量指数 (BMI) z-score 在两组中保持稳定.
结论:
- 在RhGH治疗开始时开始的一年饮食咨询,并没有显著提高GHD的青春期前儿童的生长反应.
- 这些发现表明,虽然营养咨询很重要,但在这种人群中,在RhGH治疗的前两年内,它可能不会显著改变生长结果.
相关概念视频
Nature and Nurture
22.2K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.2K
Role of Hematopoietic Growth Factors
3.1K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
3.1K
Hypoglycemia and Glucagon
835
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
835
Oxygen Requirements and Growth Patterns
1.2K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.2K
Hormones and Bone Tissue
3.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.7K
Insulin: Dosing Regimen and Adverse Effects
685
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
685


