小肠克罗恩病中的便calprotectin和细分炎症:基于囊内镜的研究
Mariana Souto1,2,3, Ana Isabel Ferreira1,2,3, João Gonçalves1,2,3
1Gastroenterology Department, Unidade Local de Saúde do Alto Ave, 4835-044 Guimarães, Portugal.
Biomedicines
|September 27, 2025
概括
便calprotectin (FC) 与克罗恩氏病 (CD) 中小肠 (SB) 炎症相关,特别是在远端段. 然而,FC对于检测近端SB炎症是不可靠的,这强调了囊内镜的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病是什么
- 诊断标记器 诊断标记器
背景情况:
- 便中的calprotectin (FC) 是胃肠道炎症的标志物.
- 在克罗恩氏病 (CD) 中检测小肠 (SB) 炎症的实用性受到争议.
- 小肠囊内镜 (SBCE) 是SB炎症的关键诊断工具.
研究的目的:
- 在CD患者中研究FC水平和SB炎症活性之间的关联.
- 为了确定FC在识别不同SB段的炎症中的可靠性.
- 为区分疾病模式建立FC切线.
主要方法:
- 87名接受SBCE和FC测试的SB-CD患者的回顾性队列研究.
- 排除同时患有结肠炎症的患者.
- 根据易斯评分 (LS) 在近位,远位或泛SB三位体中对SB炎症的分类.
主要成果:
- 随着SB炎症的增加,FC水平呈现上升趋势:58μg/g (没有炎症) 到400μg/g (全SB炎症).
- 在第二和第三个SB tertiles中,FC与LS相关,但不是第一个.
- 在泛-SB疾病中,FC明显高于孤立的近端或偏端炎症.
结论:
- FC与远端SB (第二和第三三层) 的SB病变具有正相关性.
- FC不是近接SB炎症 (第一三位) 的可靠标志物.
- 在CD患者中,SBCE对于诊断近位SB炎症至关重要.
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