雷宁-血管酶系统与易布鲁替尼相关心血管不良事件之间的关联:一个翻译队列研究
Jonaz Font1,2, Amir Hodzic3,4, Angélique Da-Silva1,5
1INSERM U1086 ANTICIPE, Université de Caen Normandie, Normandie Université, Biology-Research Building, Avenue de la Côte de Nacre, F-14000 Caen, France.
Biomedicines
|September 27, 2025
概括
血素水平在基线上升预测与ibrutinib治疗的患者心血管不良事件 (CVAEs). 这一发现表明,氨酸- ангиотензин- 阿尔多素系统在与易布鲁替尼相关的心血管毒性中可能发挥作用.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 易布鲁替尼治疗与心血管不良事件 (CVAE) 的增加有关,包括心房动,高血压,心力衰竭和心室节律失常.
- 这些与易布鲁替尼相关的CVAE的预测因子尚不清楚,特别是关于氨酸-血管新生素系统.
研究的目的:
- 为了确定与ibrutinib相关的CVAE相关的基线患者特征.
- 研究氨酸 - 血管酶系统参数在预测易布鲁替尼治疗期间CVAE中的特定作用.
主要方法:
- 对接受ibrutinib的B细胞恶性瘤患者进行前性单中心队列研究.
- 基线人口学,临床,生物标志物 (炎症,纤维化,神经激素) 和心声学参数的系统评估.
- 综合CVAE终点包括心房动,新的/恶化的高血压,新的/恶化的心力衰竭和心室节律失常.
主要成果:
- 在25名患者中,有7名患者在平均672天的随访期间共经历了9次CVAE.
- 升高的血二基线水平 (>1336.10 pg/mL) 与CVAE发生有显著的相关性 (57%对11%,p=0.032).
- 在患有CVAE的患者中观察到更高的血阿尔多素水平,但这没有达到统计学意义 (p=0.058).
结论:
- 基线血二水平是IBRUTINIB治疗患者中CVAE的不可变的预测指标.
- 血中阿尔多素水平显示出与CVAE相关的趋势.
- 这些发现表明,氨酸- ангиотензин- 阿尔多斯特系统在易布鲁替尼引起的心血管毒性中可能发挥作用,因此需要在更大规模的研究中进一步调查.
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