穿皮脊髓刺激调节脊髓反射回路刺激能力在脊髓损伤的人
Evan B Sandler1, Jennifer Ann Iddings1, Karen Minassian2
1Crawford Research Institute, Shepherd Center, Atlanta, GA 30309, USA.
在脊髓损伤 (SCI) 后,单位连续穿皮脊髓刺激 (TSS) 有效调节脊髓反射回路. 这种非侵入性方法显示了对脉冲抑郁 (PPD) 和曲线下面区域 (AUCdep) 抑郁的显著变化.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 穿皮脊柱刺激 (TSS) 是一种调节脊柱反射刺激的非侵入性方法.
- 后部根肌 (PRM) 反射被用来评估TSS后的脊柱电路刺激性变化.
- 刺激参数显著影响PRM反射反应.
研究的目的:
- 为了比较三个TSS条件 (单位连续,单位爆发,双位连续) 对soleus PRM反射反应的影响.
- 调查TSS对性电生理学测量的影响.
- 评估生物力学和电生理学的性测量之间的相关性.
主要方法:
- 我们比较了三个TSS条件:单站连续 (SS-CONT),单站爆发 (SS-BURST) 和双站连续 (DS-CONT).
- 刺激参数:50 Hz,80%的索莱斯反射值 (RT),持续时间30分钟.
- 测量了单独的PRM反射指数 (RT,RA1.2xRT,斜率,AUC) 和配对脉冲指数 (PPD,AUCdep).
- 评估足克隆斯第一次下降游览 (FDE) 生物力学性.
主要成果:
- 整个组的分析显示,PPD和AUCdep显著下降.
- 在SS-CONT条件下,特别观察到PPD和AUCdep的显著下降.
- 没有发现其他PRM反射指数或FDE跨条件的显著变化.
- 在FDE和PRM反射参数之间没有发现基线相关性.
结论:
- 单位连续TSS (80%soleus RT) 调节了向的脊柱反射回路,通过调节和测试刺激反应的变化证明了这一点.
- 这项研究表明,伸展诱导的足底动可能与电生理学测试结果不一致相关.
- TSS参数,特别是连续单位应用,对于有效的脊柱反射调制至关重要.
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