相关实验视频

Updated: Jan 16, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

在不同类型的氨基粉症中,十二指甲腺参与的比较性组织病理学特征

Anna Tebenkova¹, Zarina Gioeva¹, Nikolay Shakhpazyan¹

¹Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.

|September 27, 2025

概括

十二指肠活检可能会错过系统性粉症,特别是ATTR粉症. 在更深层中发现了大量的粉样蛋白沉积物,特别是AL kappa,影响了诊断和GI出血等并发症.

科学领域:

胃肠病学胃肠病学
病理学病理学病理学
在瘤学瘤学.

背景情况:

系统性amyloidosis经常影响十二指肠.
了解十二指甲状腺粉症的分布对于准确的诊断至关重要.

研究的目的:

描述各种十二指甲粉样性粉症类型的组织学分布.
为了提高十二指肠活检对粉样性粉症的诊断价值.

主要方法:

对21个活检和16个尸检十二指肠样本进行了回顾性观察性研究.
使用综合抗体面板进行粉样类型的免疫组织化学分析.

主要成果:

鉴定出了AL羔羊,AL卡帕,跨甲状腺素 (ATTR) 和AA氨基粉症.
粉样蛋白沉积物主要存在于肌肉粘膜和粘膜下 (89%),较少存在于自身层 (78%).
艾尔·卡帕粉样粉症显示出最广泛的沉积物;AA粉样粉症与肠道出血有关,原因是血管薄膜自身的脆弱性.

结论:

表面的十二指管活检可能会导致错误的阴性氨基粉症诊断.
ATTR氨基粉症罕见地涉及粘膜,增加了假阴性风险.
准确的打字和活检深度对于管理十二指甲状腺粉症及其并发症至关重要.

关键词:

尸体解剖尸体解剖是什么意思活组织活检十二指甲粉样性粉症胃肠道的胃肠道是什么组织病理学组织病理学免疫组织化学免疫组织化学系统性氨基粉症.

更多相关视频

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease

Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease

Published on: April 19, 2021

相关概念视频

Histology of the Small Intestine

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...

Amyloid Fibrils

Amyloid Fibrils