心率变化动态作为急性缺血性中风后功能恢复和死亡率的预测因素
Oana Elena Sandu1,2, Carina Bogdan1, Adrian Apostol1
1Department VII, Internal Medicine II, Discipline of Cardiology, "Victor Babeş" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timişoara, Romania.
在急性缺血性中风 (AIS) 后,心率变化 (HRV) 改善,较高的NN间隔标准偏差 (SDNN) 预测了更好的结果. 自主平衡恢复有助于功能恢复和中风后的生存.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 医学统计 医学统计
背景情况:
- 自主功能障碍在急性缺血性中风 (AIS) 后很常见,影响恢复和生存.
- 心率变化 (HRV) 衡量自主平衡,但其在AIS中的预后作用需要进一步评估.
研究的目的:
- 为了前性地评估AIS后HRV的时间变化.
- 确定HRV参数对AIS患者功能结果和死亡率的预后意义.
主要方法:
- 148名AIS患者在基线,1个月和3个月接受HRV评估 (SDNN,LF,HF,LF/HF比率).
- 使用修改的兰金尺度 (mRS) 评估的功能结果;在1个月和3个月记录的死亡率.
- 多变量逻辑回归确定了不良结果 (mRS>2) 和死亡率的预测因素.
主要成果:
- 在3个月的时间里,HRV呈现出转向表交主导的转变 (增加SDNN,HF;减少LF,LF/HF比率).
- 更高的SDNN强烈预测了更好的功能状态和有利的结果 (p < 0.001).
- 较高的LF/HF比率预测了基线和3个月的不良结果 (p < 0.01,p < 0.001). 在3个月内12.2%的死亡率,由并发症和改变的HRV预测.
结论:
- 脑卒中后恢复包括逐渐恢复自主平衡,由HRV变化表明.
- 较高的SDNN和较低的LF/HF比率与AIS后功能恢复和生存的改善有关.
- HRV分析为AIS患者的风险分层提供了有价值的预后见解.
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