在COVID-19大流行期间,子宫内暴露于SARS-CoV-2的儿童的神经精神运动发育
Felipe Motta1, Maria Eduarda Canellas-de-Castro1,2, Geraldo Magela Fernandes1
1Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.
Biomedicines
|September 27, 2025
概括
在子宫内暴露于SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 的婴儿在6个月和12个月时表现出发育迟缓,特别是在语言技能方面. 对这些孩子来说,长期跟踪对这些孩子来说至关重要.
科学领域:
- 儿科 儿科 儿科
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 对子宫内SARS-CoV-2暴露对儿童发育的影响的理解有限.
- 需要研究对神经发育的影响.
研究的目的:
- 为了验证宫内SARS-CoV-2暴露对儿童神经发育的影响.
- 评估出生后6个月和12个月的发育结果.
主要方法:
- 在怀孕期间出生于患有SARS-CoV-2的母亲的婴儿的前性描述分析研究.
- 在6个月和12个月时使用贝利-III尺度评估的神经发育.
- 统计分析包括使用邦费罗尼校正和回归模型的ANOVA.
主要成果:
- 评估了269名婴儿;大多数是满期的婴儿,出生时体重适当.
- 26%的婴儿在至少一个贝利-III域中表现出发育迟缓.
- 语言领域受到显著影响,特别是在接近分娩的婴儿身上 (p < 0.05).
结论:
- 宫内SARS-CoV-2暴露与6个月和12个月的发育延迟有关.
- 语言发展是特别脆弱的.
- 强调持续对暴露新生儿进行临床监测的重要性.
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