50岁后MASLD的性别差异:表现,诊断和临床影响
Ilaria Milani1, Maria Eugenia Parrotta2,3, Luca Colangeli2,3
1Department of Medico-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, University of Rome La Sapienza, 04100 Latina, Italy.
Biomedicines
|September 27, 2025
概括
肥胖和2型糖尿病的老年女性表现出与男性相似或更糟糕的代谢性肝病概况. 诊断脂肪肝的标准标记在女性中不那么准确,这凸显了需要性别特异性标准的需要.
科学领域:
- 肝病学和代谢疾病
- 心脏代谢健康状况
- 疾病中的性别差异.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与年龄,更年期,肥胖和2型糖尿病 (T2D) 有关.
- 具有这些风险因素的老年人 (≥50岁) 是MASLD研究的关键人口.
- 了解MASLD呈现的性别特异性对于有效管理至关重要.
研究的目的:
- 评估患有MASLD,肥胖症和/或T2D的个体在人类学和临床特征上的基于性别的差异.
- 在目标人群中,在男性和女性之间比较肝硬化和纤维化的非侵入性标志物.
- 评估脂肪肝指数 (FLI) 的诊断准确性,以跨性别检测肥胖症.
主要方法:
- 观察性研究收集人体测量数据,临床参数和非侵入性肝脏指数 (FLI,FIB-4,FibroScan®).
- 对213名患有MASLD,肥胖和/或T2D的患者 (65.7%为女性,中位数年龄为63岁) 的分析.
- 在男性和女性参与者之间比较临床资料和诊断标记的准确性.
主要成果:
- 女性的BMI和腰与身高比率 (WHtR) 较高,比男性更频繁地超过风险切断值.
- 虽然男性的转氨基酶含量较高,但女性更常超过性别特定的值.
- 脂肪肝指数 (FLI) 对肥胖症的诊断准确性在女性 (AUC 0.655) 与男性 (AUC 0.863) 相比显著较低.
结论:
- 与男性相比,患有内脏肥胖的绝经后妇女患有类似或更严重的肝脏和心脏代谢问题.
- 标准的MASLD诊断标记物,如氨酶和FLI,在女性中显示精度降低.
- 需要建立性别特定的诊断标准,并加强对中部肥胖的老年女性中MASLD的临床警.
关键词:
纤维扫描扫描 (FibroScan) 是一种纤维扫描.马斯尔德 马斯尔德是什么意思有纤维化的纤维化.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖性差异的性别差异.蒸症是一种蒸症.2 型糖尿病 2 型糖尿病更多相关视频
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