主体遗传效应和表型景观的流血细菌肠型在一大群羊群
Yukun Zhang1, Fadi Li1, Xiaoxue Zhang2
1State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730020, China.
Animals : an open access journal from MDPI
|September 27, 2025
概括
确定了两种羊肠类型:E1 (多种属) 和E2 (Prevotella-主导). E2羊的生长较好,但料效率较低,肠型遗传性与特定的宿主基因有关.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 遗传学 遗传学 是一个
背景情况:
- 肠道微生物群的肠型对于动物健康和生产至关重要.
- 在绵羊中,肠型的识别,其影响因素,以及与性能和遗传学的关联是不太了解的.
研究的目的:
- 在大型绵羊群中研究宿主遗传效应和肠细菌肠型的表型景观.
- 为了确定羊的肠类型,并分析它们对生长,料效率,肉类产量和宿主遗传学的影响.
主要方法:
- 16S rRNA基因测序来自1150只羊的反动物内容.
- 基因级聚类,广泛的表型数据分析 (47个特征) 和全基因组再测序.
- 微生物社区结构的两部分β回归模型和并发网络分析.
主要成果:
- 确定了两种不同的肠类型:E1 (多种属) 和E2 (Prevotella-主导).
- E2羊表现出优越的生长和肉类产量,但料效率较低,脂肪沉积增加.
- 肠型遗传率估计为0.47,GWAS确定了与CHODL和ENPP6基因相关的五个关键遗传标记,影响了58个细菌基因.
结论:
- 肠类型显著影响绵羊中的微生物群体结构和宿主性能.
- 宿主遗传在塑造乳头肠型中起着至关重要的作用,为遗传改进提供了目标.
- 研究结果提供了关于微生物相互作用的见解,以提高反动物生长性能.
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