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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

501
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Updated: Jan 16, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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患精神病超高风险个体的外围BDNF水平:系统性审查

Omar Contreras1, Carla Rivera1, Carolina Villaseca1

  • 1Escuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.

Brain sciences
|September 27, 2025
PubMed
概括

在患精神病超高风险的人群中,外围大脑衍生神经缩因子 (BDNF) 水平显示出不一致的结果. 目前的证据不支持其作为预后生物标志物的使用,因为异质性和样本大小小小.

关键词:
大脑衍生的神经营养因子第一个情节精神病的精神病.周边生物标志物 周边生物标志物精神分裂症是一种精神分裂症.超高风险 超高风险 超高风险

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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
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Last Updated: Jan 16, 2026

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科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 生物标志物研究 生物标志物研究

背景情况:

  • 大脑衍生神经营养因子 (BDNF) 对大脑功能至关重要,其水平变化与精神疾病有关.
  • 患有精神病超高风险 (UHR) 个体的外围BDNF水平需要进一步调查,因为发现不一致.
  • 本综述检查了与健康对照组 (HC),第一发精神病 (FEP) 和慢性精神分裂症 (CS) 相比,UHR人群中的BDNF水平.

研究的目的:

  • 综合关于UHR个体外围BDNF水平的证据.
  • 为了在UHR,HC,FEP和CS组中比较BDNF水平.
  • 评估BDNF作为精神病风险和临床过程的生物标志物的潜力.

主要方法:

  • 在PubMed,Scopus和Web of Science的系统文献搜索.
  • 包括8项报告基线外围BDNF水平的研究.
  • 由于临床和方法异质性,对发现的叙述综合.

主要成果:

  • 与对照组相比,UHR个体的外围BDNF水平存在不一致的发现.
  • 一些研究报告了UHR中较低的BDNF,而另一些研究发现没有差异或水平更高.
  • 纵向分析并没有始终表明BDNF的预后价值.

结论:

  • 目前关于UHR个体中外围BDNF的证据不一致,并受到小样本大小和方法异质性的限制.
  • 周围BDNF目前不被支持作为精神病的预后生物标志物.
  • 需要进行更大规模的标准化研究,以澄清BDNF在精神病风险生物标志物框架中的潜在作用.