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患精神病超高风险个体的外围BDNF水平:系统性审查

Omar Contreras¹, Carla Rivera¹, Carolina Villaseca¹

¹Escuela de Medicina, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.

|September 27, 2025

概括

在患精神病超高风险的人群中,外围大脑衍生神经缩因子 (BDNF) 水平显示出不一致的结果. 目前的证据不支持其作为预后生物标志物的使用,因为异质性和样本大小小小.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
生物标志物研究生物标志物研究

背景情况:

大脑衍生神经营养因子 (BDNF) 对大脑功能至关重要,其水平变化与精神疾病有关.
患有精神病超高风险 (UHR) 个体的外围BDNF水平需要进一步调查,因为发现不一致.
本综述检查了与健康对照组 (HC),第一发精神病 (FEP) 和慢性精神分裂症 (CS) 相比,UHR人群中的BDNF水平.

研究的目的:

综合关于UHR个体外围BDNF水平的证据.
为了在UHR,HC,FEP和CS组中比较BDNF水平.
评估BDNF作为精神病风险和临床过程的生物标志物的潜力.

主要方法:

在PubMed,Scopus和Web of Science的系统文献搜索.
包括8项报告基线外围BDNF水平的研究.
由于临床和方法异质性,对发现的叙述综合.

主要成果:

与对照组相比,UHR个体的外围BDNF水平存在不一致的发现.
一些研究报告了UHR中较低的BDNF,而另一些研究发现没有差异或水平更高.
纵向分析并没有始终表明BDNF的预后价值.

结论:

目前关于UHR个体中外围BDNF的证据不一致,并受到小样本大小和方法异质性的限制.
周围BDNF目前不被支持作为精神病的预后生物标志物.
需要进行更大规模的标准化研究,以澄清BDNF在精神病风险生物标志物框架中的潜在作用.

关键词:

大脑衍生的神经营养因子第一个情节精神病的精神病.周边生物标志物周边生物标志物精神分裂症是一种精神分裂症.超高风险超高风险超高风险

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