威胁感知的高风险模型调节了对安慰剂和诺塞博效应以及功能性体力障碍的学习
1Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Brain sciences
|September 27, 2025
概括
与功能性体力障碍 (FSD) 相关的学习的nocebo和安慰剂效应受心理社会因素和催眠能力的影响. 这些因素调节威胁感知,影响自主神经系统失调和体质症状.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 内部医学 内部医学
背景情况:
- 功能性体力障碍 (FSD) 在初级保健中存在重大挑战,通常缺乏明确的病理生理学.
- 这些疾病与学习的nocebo和安慰剂体质效应有关,可能源于对假入侵手术的急性反应.
- 患有FSD的患者经常过度利用医疗服务,并面临因无意造成的阳性损伤导致的发病风险.
研究的目的:
- 探索条件响应模型 (CRM) 和高风险威胁感知模型 (HRMTP) 在理解FSD方面.
- 调查心理社会因素,特征催眠能力和威胁感知在调节体质效应和FSD中的作用.
- 检查心率变化降低 (HRV),自主神经系统 (ANS) 失调和FSD之间的关系.
主要方法:
- 审查和综合条件响应模型 (CRM) 和高风险威胁感知模型 (HRMTP).
- 对大量FSD患者 (N = 6,891) 的HRV现有数据的分析.
- 在患有慢性疼痛的FSD患者中威胁诱导期间手部温度 (PTI) 的悖论性升高的调查 (n = 224) 以及其与不良童年经历 (ACE) 的关联.
主要成果:
- 在大量FSD患者的样本中观察到HRV降低.
- 患有慢性疼痛的FSD患者中有很大一部分 (50%) 在威胁诱导期间表现出PTI,这证实了HRMTP预测将PTI与ANS失调和ACE联系起来.
- 发现心理社会因素和催眠能力调节威胁感知,影响ANS失调和体质效应.
结论:
- HRMTP通过识别调节威胁感知的心理社会风险因素,为了解FSD提供了一个框架.
- 心理社会因素和催眠能力在通过ANS失调来发展和维持FSD中起着至关重要的作用.
- 识别这些因素可以通过纳入FSD诊断,超越仅仅排除病理生理学,并为干预提供潜在的目标.
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