蛋白S和妊娠中高血压的因果风险:孟德尔随机化研究
Mengqi Cai1,2, Wenrui Lv2, Yan He1
1Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Department of Epidemiology, School of Public Health, Suzhou Medical College, Soochow University, Suzhou 215123, China.
Healthcare (Basel, Switzerland)
|September 27, 2025
概括
血中Selenoprotein S (SELENOS) 水平升高因果性地增加了怀孕引起的高血压 (PIH) 的风险. 这一发现支持SELENOS作为改善母亲和胎儿结果的潜在可修改风险因素.
科学领域:
- 遗传学 遗传学 是一个
- 产科 产科 产科 产科 产科
- 营养科学 营养科学
背景情况:
- 妊娠引起的高血压 (PIH) 影响全球10%的怀孕,对孕产妇和产周死亡率作出重大贡献.
- 含量与PIH之间的联系受到争议,观察性研究受到混因素的阻碍.
- 载体蛋白质蛋白S (SELENOS) 涉及氧化应激和炎症,但其在PIH中的因果作用尚不清楚.
研究的目的:
- 通过使用孟德尔随机化来调查血S蛋白 (SELENOS) 水平与妊娠引起的高血压 (PIH) 风险之间的潜在因果关系.
- 提供遗传证据,为PIH的预防策略提供信息.
主要方法:
- 使用全基因组关联研究 (GWAS) 总结统计数据进行了两样本的门德尔随机化 (MR) 分析.
- 数据来源于INTERVAL研究和FinnGen联盟,专注于欧洲祖先的个人.
- 逆变量加权 (IVW) 方法是主要分析,并补充了全面的灵敏度分析以确保稳定性.
主要成果:
- 血SELENOS水平升高与PIH (OR 1.078,p=0.001) 的风险增加显著相关,先前存在的高血压 (PEH) (OR 1.232,p<0.001) 和妊娠高血压 (GH) (OR 1.111,p=0.001).
- 预示性关联被观察到在孕前和慢性高血压之间叠加 (OR 1.590,p=0.019).
- 该研究包括3301个SELENOS水平的样本和大量的PIH,PEH,GH和对照病例.
结论:
- 这项研究提供了强有力的遗传证据,证明了血SELENOS水平与PIH风险之间的因果关系.
- SELENOS被确定为潜在的可修改风险因素,这表明怀孕期间个性化管理的临床影响.
- 这些发现支持早期查和有针对性的干预措施,以改善孕产妇和胎儿健康结果.
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