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相关概念视频

Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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基于白的多功能益生菌系统,通过喷雾干燥制备.

Anna Gościniak1, Lidia Tajber2, Piotr Szulc3

  • 1Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.

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概括

选择正确的 (Sambucus nigra L.) 品种,并使用带有二氧化载体的银寡糖 (GOS) 产生稳定,生物活性粉末. 这些功能性成分提供了益生菌的益处和有效的聚醇供应营养药.

关键词:
它们是安托西安氨酸.基托氧糖 (COS) 是一种基托氧糖 (COS)降解动力学的降解动力学.桑的提取物 桑的提取物银河氧糖 (Galactooligosaccharides,简称GOS) 是一种有氧糖.聚醇是一种多醇.石是什么意思? 石是什么意思?喷雾干燥 喷雾干燥

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科学领域:

  • 食品科学 食品科学 食品科学
  • 营养药化学 营养药化学
  • 植物生物化学 植物生物化学

背景情况:

  • 老树 (Sambucus nigra L.) 富含抗氧化剂和抗糖尿病性质的抗生素和生物活性物质.
  • 种植方式的多样性会影响桑的化学成分和生物活性,因此需要对功能成分进行仔细的植物材料选择.
  • 现有的配方需要提高树活性化合物的稳定性和生物可用性.

研究的目的:

  • 为了比较12种桑基因型的多含量,抗氧化活性和抗糖化潜力.
  • 为了开发稳定的,喷雾干燥的树粉末,使用银类寡糖化物 (GOS) 或类寡糖化物 (COS) 作为载体,有或没有合.
  • 评估载体系统和二氧化对抗生素保留,热稳定性和技术性质的影响.

主要方法:

  • 对12种桑基因型进行总多,抗氧化活性和抗糖化潜力的比较分析.
  • 使用GOS或COS载体,有或没有合体二氧化,喷雾干燥大树提取物.
  • 使用差分扫描热度计,热重力测量分析,降解动力学建模以及湿度含量,形态和流动性的评估来表征粉末.

主要成果:

  • "萨米尔1"基因型显示出一个有前途的组合. 与COS.COS相比,基于GOS的粉末显示出优越的抗素保留和热稳定性.
  • 结合合体二氧化显著改善了粉末的回收,减少了聚合,并提高了流动性,而不会影响酸盐含量.
  • 所有开发的长粉都表现出低湿度,有利的形态,并保持了功能活性,满足了保质期提取物的稳定性要求.

结论:

  • 对于优化功能性成分开发而言,策略性选择像"萨米尔1"这样的树品种至关重要.
  • GOS-载体系统有效地稳定了长树的安东和生物活性物质,提高了它们在营养药应用中的交付和保质期.
  • 这些多功能长粉结合了益生菌功能与强大的抗氧化和抗糖化特性,为食品和制药行业提供了巨大的潜力.