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在系统性硬化症患者中评估心脏病的参与
Chiara Pellicano1, Giancarlo D'Ippolito1, Annalisa Villa1
1Department of Translational and Precision Medicine, La Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Biomolecules
|September 27, 2025
概括
系统性硬化症患者表现出高心综合征 (CRS) 标志物,表明早期心脏和损伤. 特定的生物标志物,如 galectin-3 和 suPAR,在SSc中检测CRS具有前途,有助于早期诊断和管理.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 类风湿病学 类风湿病学
- 生物标志物发现发现
背景情况:
- 系统性硬化症 (SSc) 是一种严重的自身免疫性疾病,死亡率高,通常由肺动脉高血压 (PAH) 复杂化,心脏参与导致右心力衰竭 (HF) 和慢性病 (CKD).
- 心脏病综合征 (CRS),特别是2型 (慢性HF的二次性CKD),突出了心血管和系统之间的复杂联系.
- 现有的CRS诊断标记通常是非特异性的,需要探索更精确的生物标记物.
研究的目的:
- 在SSc患者中全面评估与CRS相关的心脏和损伤标志物.
- 为了比较SSc患者的CRS标志物水平与健康对照 (HC).
- 调查SSc.中这些标志物与脏/心脏超声波参数之间的关联.
主要方法:
- 评估了特定的CRS生物标志物,包括加列-3,可溶性尿素酶等离子体激活体受体 (suPAR),中性粒细胞凝酶相关性脂卡林 (NGAL) 和N终端亲B型尿素 (NT-proBNP).
- 在SSc患者 (有或没有临床诊断的CRS) 和HC患者之间比较标记水平.
- 与抗性指数 (RRI) 和其他超声波参数相关的生物标志物水平.
主要成果:
- 与HC相比,SSc患者的CRS标志物水平明显较高 (p < 0.001).
- 被诊断为CRS的SSc患者表现出高水平的加勒-3,suPAR,sNGAL和uNGAL (p <0.05) 与没有CRS的患者相比.
- 在RRI和NT-proBNP (r = 0.335,p < 0.05) 以及RRI和suPAR (r = 0.331,p < 0.05) 之间观察到显著的正相关性.
结论:
- NT-proBNP,suPAR,galectin-3,sNGAL和uNGAL被认为是早期检测SSc中的心脏和脏参与的有希望的生物标志物.
- 这些生物标志物可能有助于识别患有心脏病并发症风险的SSc患者.
- 需要进一步的研究来验证这些发现,并将其纳入临床实践,以改善SSc管理.
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