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基于EET的治疗药物减轻索拉费尼布相关的淋巴细胞损伤.

Abhishek Mishra1, Marcus de Bourg2, Rawand S Mohamed2

  • 1Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Biomolecules
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概括

这项研究表明,8,9-epoxyeicosatrienoic acid (8,9-EET) 的类似物可以保护细胞免受索拉尼毒性影响. 一种类似的MDB-52a减少了细胞死亡,并抵消了与脏损伤相关的基因变化.

关键词:
环氧脂类物质 (Epoxylipids) 是一种环氧脂类物质.介管细胞是介管细胞.毒性 毒性 毒性在conephrology上使用.葡萄细胞 (podocytes) 是一个细胞.

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科学领域:

  • 腎臟病學 (nephrology) 是一種醫學.
  • 分子生物学分子生物学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 索拉费尼布是一种氨酸激酶抑制剂,可导致脏损伤.
  • 淋巴细胞是索拉费尼布诱导的毒性的主要目标.
  • 目前正在研究8,9-epoxyeicosatrienoic acid (8,9-EET) 的类似物是否具有保护作用.

研究的目的:

  • 为了研究索拉费尼布诱导的人类介质细胞 (HRMC) 和 podocytes 的毒性.
  • 为了检查8,9-EET类似物对索拉费尼布诱导的损伤的保护潜力.
  • 为了确定特定的8,9-EET类型,减轻索拉费尼布毒性.

主要方法:

  • HRMCs和podocytes被单独暴露于索拉费尼布或与8,9-EET类似物一起.
  • 进行了细胞活力测定和caspase 3/7活性测量.
  • 使用RNA测序和对公众基因表达数据 (Nephroseq) 的分析.

主要成果:

  • 索拉芬尼以剂量依赖的方式降低了细胞活力和增加了细胞亡.
  • 在20种8,9-EET类型中,有5种具有显著的细胞保护作用.
  • 索拉费尼布改变了细胞周期和Raf/MEK/ERK通路中的基因;MDB-52a调节了ANGPTL4和ACTA2的表达,与淋巴结核硬化症标志物相关联.

结论:

  • 8,9-EET模拟MDB-52a在抵消索拉芬尼布诱导的基因破坏方面显示出有前途.
  • 在实验室中,MDB-52a对与sorafenib相关的损伤具有保护作用.
  • 用8,9-EET类似物准淋巴细胞可能为索拉尼布毒性提供治疗策略.