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Updated: Jan 16, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
09:32

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

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基于EET的治疗药物减轻索拉费尼布相关的淋巴细胞损伤

Abhishek Mishra1, Marcus de Bourg2, Rawand S Mohamed2

  • 1Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Biomolecules
|September 27, 2025
PubMed
概括

这项研究表明,8,9-epoxyeicosatrienoic acid (8,9-EET) 的类似物可以保护细胞免受索拉尼毒性影响. 一种类似的MDB-52a减少了细胞死亡,并抵消了与脏损伤相关的基因变化.

关键词:
环氧脂类物质 (Epoxylipids) 是一种环氧脂类物质.介管细胞是介管细胞.毒性 毒性 毒性在conephrology上使用.葡萄细胞 (podocytes) 是一个细胞.

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