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线粒体反应性氧物种:长期COVID和尖端蛋白相关损伤中的统一机制:叙述性审查

Eunseuk Lee¹, Adaobi Amelia Ozigbo², Joseph Varon^3,4

¹Department of Internal Medicine, Rutgers Health/Community Medical Center, Toms River, NJ 08755, USA.

|September 27, 2025

概括

长期的COVID和疫苗后损伤可能源于线粒体功能障碍和氧化应激. 通过向疗法和生物标志物恢复线粒体健康,为这些复杂的后病毒性疾病提供了新的治疗途径.

科学领域:

生物医学是生物医学.
病理生理学病理生理学
分子生物学分子生物学

背景情况:

SARS-CoV-2 感染 (长期COVID) 的急性后续症状表现为持续的疲劳,认知障碍和多系统功能障碍.
线粒体功能障碍和氧化应激越来越多地被认为是驱动长期COVID和疫苗后后果的核心机制.
SARS-CoV-2 感染破坏了线粒体的生物能量,导致线粒体反应性氧物种 (mtROS) 增加和线粒体衰变受损.

研究的目的:

审查长期COVID和疫苗后损伤中线粒体氧化还原信号和受损的线粒体的作用.
探索潜在的生物标志物和治疗策略,以恢复线粒体健康.
将长期COVID重新定义为由氧化还原失衡驱动的线粒体疾病.

主要方法:

文献综述综合了当前关于后病毒综合征中线粒体功能障碍的证据.
讨论转化生物标志物和非侵入性诊断技术.
探索基于药物,非药物,营养和成像的治疗方法.

主要成果:

线粒体功能障碍,其特点是膜完整性发生变化,mtROS增加和线粒体吸食功能受损,有助于慢性炎症和多系统症状.
氧化还原失衡和无法清除受损的线粒体是长期COVID和疫苗后损伤病理生理学的核心.
针对线粒体健康的生物标志物和向疗法为个性化治疗提供了有希望的途径.

结论:

长期COVID和相关的后病毒综合征可以被概念化为根植于氧化还原失衡的线粒体疾病.
通过新的治疗策略恢复线粒体功能,有可能有效地管理患者.
需要进一步的临床试验来验证这些线粒体复苏方法的广泛临床应用.

关键词:

这就是SARS-CoV-2病毒.自自是自的过程.生物标志物生物标志物长时间的COVID.线粒体功能障碍线粒体功能障碍线粒体的反应性氧物种.线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.

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