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Updated: Jan 16, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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利用p97/VCP:为下一代癌症治疗药物提供转变性的AAA+ ATPase标

Maria Janina Carrera Espinoza1, Sarah K Tucker1, Sruthi Sureshkumar1

  • 1Department of Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA.

Cancers
|September 27, 2025
PubMed
概括

向含有瓦洛辛的蛋白质 (VCP) /p97可能会选择性地杀死癌细胞. 这种蛋白质对于蛋白质降解至关重要,其抑制可以导致癌细胞死亡.

关键词:
CB-5083 这是一本书.CB-5339 这是一本书.这是一个VCPVCP.癌症 癌症 癌症 癌症 癌症细胞内膜网膜的压力应激在P97中,P97是P97的代码.含有瓦洛的蛋白质.

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