临床病理因素影响晚期宫癌患者的预后,这些患者同时接受化学辐射治疗
Maitreyee Parulekar1,2, Min Kyung Kim1, Joseph J Noh1,3
1Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
Cancers
|September 27, 2025
概括
准大动脉淋巴结转移和肥胖是局部晚期宫癌 (LACC) 患者用化疗治疗的显著预后因素. 识别这些因素有助于制定量身定制的治疗策略,以改善结果.
科学领域:
- 妇科瘤学 妇科瘤学
- 辐射瘤学 辐射瘤学
- 临床癌症研究 临床癌症研究
背景情况:
- 同时化学辐射治疗 (CCRT) 是局部晚期宫癌 (LACC) 的标准.
- 在LACC中对CCRT的结果和预后因素需要进一步定义.
- 确定预后因素对于完善治疗策略至关重要.
研究的目的:
- 确定接受终极CCRT的LACC患者的显著预后因素.
- 评估临床病理学变量对生存结果的影响.
- 为LACC提供风险适应的治疗方法.
主要方法:
- 对128名LACC患者进行了回顾性分析,这些患者接受了最终的CCRT治疗 (2003-2022年).
- 评估临床病理学变量,包括瘤特征和转移.
- 使用卡普兰-梅尔曲线和考克斯比例危险模型进行生存分析.
主要成果:
- 副大动脉淋巴结转移显著增加复发风险 (OR=5.892) 和降低生存率 (PFS,OS,TFI).
- 肥胖 (BMI ≥25 kg/m2) 与更高的复发风险 (OR=2.737) 和降低PFS相关.
- 阶段IIIC1r是最常见的阶段,突出了疾病的发病率.
结论:
- 副大动脉淋巴结转移和肥胖是用CCRT治疗LACC的关键负面预后因素.
- 这些发现支持风险分层和个性化治疗策略.
- 辅助疗法可以改善高风险LACC亚组的结果.
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