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帕克利塔塞尔和塞法洛曼宁协同诱导三阴性乳腺癌中通过氧气调节的细胞死亡途径诱导PANOPTOSIS

Xinyu Gao^1,2, Kuilin Chen^1,2, Shuhui Jia^1,3

¹State Key Laboratory of Chemical Oncogenomics, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.

Antioxidants (Basel, Switzerland)

|September 27, 2025

概括

帕克利塔克塞尔和塞法洛曼宁通过诱导PANoptosis,一种编程细胞死亡途径,协同打击三阴性乳腺癌. 这种天然化合物组合提供了一种新的治疗策略,针对氧化应激和多个细胞死亡机制.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
细胞生物学细胞生物学

背景情况:

三阴性乳腺癌 (TNBC) 缺乏有效的治疗方法,需要新的治疗策略.
调节细胞死亡途径PANoptosis是癌症治疗的有希望的目标.
帕克利塔塞尔是一种常见的化疗剂,但其疗效往往有限,需要组合疗法.

研究的目的:

在TNBC中调查帕克利塔克塞尔和塞法洛曼宁的协同抗瘤作用.
阐明涉及氧气调节细胞死亡途径的潜在机制.
评估这种组合在TNBC治疗中的治疗潜力.

主要方法:

网络药理学和分子对接被用来识别潜在的协同目标.
在体外研究评估了TNBC细胞系中的细胞活力,增殖,迁移,亡和亡.
机械学研究涉及分析反应性氧物种 (ROS) 水平,DNA损伤和亡,亡和亡途径中的关键蛋白质.
在体内实验中评估了该组合的抗瘤疗效和安全性.

主要成果:

帕克利塔克塞尔-塞法洛曼宁组合证明了对TNBC细胞活力,增殖和迁移的协同抑制.
同时治疗通过增加ROS和DNA损伤诱导显著的亡,亡和PANoptosis.
该组合激活了p38,p53,RIPK1/RIPK3/MLKL和NLRP3炎症酶通路,导致细胞死亡.
在体内研究证实了该组合的强有力的抗瘤活性和有利的安全性.

结论:

帕克利塔克塞尔和塞法洛曼宁通过ROS介导的氧调节细胞死亡途径协同诱导TNBC中的PANoptosis.
这种组合代表了TNBC的新治疗策略,通过天然化合物调节氧化应激.
这些发现支持对帕克利塔克塞尔和塞法洛曼宁作为TNBC联合治疗的临床研究.

关键词:

这就是PANoptosis.这就是为什么塞法洛曼尼因 (Cephalomannine) 是一种药物.氧化应激是一种氧化应激.帕克利塔克塞尔 (paclitaxel) 的使用情况被编程的细胞死亡.三重阴性乳腺癌是什么

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