现代计算机断层扫描中的电离辐射诱导的氧化压力介导的DNA损伤:基于抗氧化剂的放射保护策略的证据
Baltasar Ramos1, Jorge Gómez-Cayupán2, Isidora Aranis3
1Radiology Department, University of Chile Clinical Hospital, Carlos Lorca 999, Independencia, Santiago 8380453, Chile.
Antioxidants (Basel, Switzerland)
|September 27, 2025
概括
计算机断层扫描 (CT) 扫描使患者暴露在电离辐射 (IR) 中,导致DNA损伤. 这项研究发现CT后DNA损伤和抗氧化活性增加,这表明需要抗氧化剂辐射保护策略.
科学领域:
- 放射学 放射学是一门学科.
- 医学物理 医学物理
- 分子生物学分子生物学
背景情况:
- 计算机断层扫描 (CT) 在现代医学中至关重要,但涉及对电离辐射 (IR) 的暴露.
- 来自CT扫描的IR暴露可能会导致DNA损伤,可能有助于癌症诊断.
- 目前的剂量减少策略可能不足,需要补充辐射保护方法.
研究的目的:
- 为了研究现代CT扫描引发的氧化应激 (OS) 介导的DNA损伤.
- 探索基于抗氧化剂的辐射保护策略的潜力.
- 为了描述CT暴露后的骨和DNA损伤的生物标志物.
主要方法:
- 展望观察性研究涉及两个组:非IR暴露 (A_NONE) 和CT暴露 (B_EXPOSURE).
- 在基线 (T_BASE) 和扫描后60分钟 (T_POST) 采集的血液样本用于生物标志物分析.
- 测量氧化应激 (OS) 生物标志物 (氧化损伤,抗氧化能力) 和DNA损伤.
主要成果:
- 在未暴露组中,OS或DNA损伤生物标志物没有显著变化.
- 接受CT检查的患者的DNA损伤显著增加 (15%).
- 在CT暴露的患者中观察到抗氧化酶活性增加,表明对OS的防御反应.
结论:
- 现代CT扫描,即使是低有效剂量,也会引起显著的DNA损伤.
- 较高的抗氧化酶活性表明细胞对IR诱导的OS的反应.
- 这些发现支持对CT手术中抗氧化剂辐射保护的进一步干预研究.
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