牙周炎,2型糖尿病和COVID-19之间的相互关系的当前景观
José Luis Muñoz-Carrillo1, Oscar Gutiérrez-Coronado1, Paola Trinidad Villalobos-Gutiérrez1
1Laboratorio de Inmunología, Centro Universitario de los Lagos, Universidad de Guadalajara, Lagos de Moreno 47460, Mexico.
International journal of molecular sciences
|September 27, 2025
概括
炎症链接牙周炎,2型糖尿病 (T2DM) 和COVID-19,通过共享的病理途径恶化疾病严重程度. 了解这些联系对于管理慢性炎症疾病至关重要.
科学领域:
- 医学科学 医学科学 医学科学
- 免疫学 免疫学 免疫学
- 慢性疾病 慢性疾病
背景情况:
- 炎症反应是牙周炎,2型糖尿病 (T2DM) 和2019年冠状病毒病 (COVID-19) 的病理生理学的核心.
- 这些疾病的同时存在与增加的临床并发症和疾病严重程度有关.
- 目前关于它们相互关系的证据不足,需要进一步研究.
研究的目的:
- 提供关于牙周炎,T2DM和COVID-19之间的相互关系的当前概述.
- 阐明这些疾病之间的共享机制和协同相互作用.
主要方法:
- 采用了一个叙事审查方法.
- 在PubMed和LILACS中对研究进行了详尽的搜索,没有日期限制.
- 使用布尔运算符的搜索术语包括"牙周病"",牙周炎"",2型糖尿病"",SARS-CoV-2"和"COVID-19".
主要成果:
- 炎症起到统一机制的作用,加剧了这些情况.
- 确定了四个共同的轴:临床病理 (系统表现),代谢 (血糖失调),酶 (改变ACE2和葡萄糖代谢) 和炎症.
- 协同作用的相互作用创造了一个恶性循环,使患者的健康状况恶化.
结论:
- 牙周炎,T2DM和COVID-19可以通过共享的炎症途径相互增强.
- 了解这些相互联系对于改善患者的治疗结果和治疗慢性炎症疾病至关重要.
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