吸烟相关遗传变异对运动后心率的影响
Habib Al Ashkar1,2, Nihad Kharrat Helu1, Nora Kovacs2,3
1Doctoral School of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary.
International journal of molecular sciences
|September 27, 2025
概括
吸烟相关的遗传变异影响运动后心率恢复,而不是休息心率. 特定的遗传风险得分与运动后心率动态变化相关,这表明在心血管风险评估中发挥了作用.
科学领域:
- 心血管生理学心血管生理学
- 人类遗传学 人类遗传学
- 运动科学 运动科学
背景情况:
- 吸烟显著影响心血管健康,增加心率并损害自主调节.
- 虽然尼古丁的急性作用是众所周知的,但与吸烟相关的心率对运动反应的遗传基础尚不清楚.
研究的目的:
- 为了研究吸烟相关的单核酸多态 (SNPs) 和身体炼后的心率 (HR) 动态之间的关联.
- 探索遗传变异对吸烟者运动心血管反应的累积影响.
主要方法:
- 661名匈牙利成年人接受了YMCA3分钟步骤测试,HR在休息和恢复期间受到监测.
- 基因分析侧重于9个与吸烟相关的SNP,风险得分来自三个关键变体 (rs2235186,rs4142041,rs578776).
- 调整后的线性回归检查了SNP和HR指数之间的关联,例如运动后HR (HR_aft),HR变化 (ΔHR) 和心率恢复 (HRR).
主要成果:
- 没有个人SNP与休息HR相关.
- 三个特定的SNP (rs2235186,rs4142041,rs578776) 与HR_aft升高,ΔHR升高,HR_max%升高和HRR降低有关.
- 一个复合的遗传风险得分显示与所有运动后HR测量有显著的相关性,表明累积的遗传影响.
结论:
- 与吸烟相关的遗传倾向会影响自主心血管对身体活动的反应.
- 特定的SNP影响运动后HR动态和恢复,独立于休息HR.
- 基因查可能有助于个性化评估吸烟者的心血管风险.
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