在Sjögren病中Sicca角膜结膜炎:诊断挑战和治疗进展
Muhammad Soyfoo1, Elie Motulsky2, Julie Sarrand1
1Department of Rheumatology, Hôpital Universitaire de Bruxelles (HUB), 1070 Bruxelles, Belgium.
International journal of molecular sciences
|September 27, 2025
概括
结膜炎 (KCS) 或干眼病 (DED) 是Sjögren病 (SD) 的一个主要并发症. 本综述详细介绍了SD患者的KCS病变发生,诊断和治疗方法.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 皮质结膜炎 (KCS) 或干眼病 (DED) 是Sjögren病 (SD) 的主要表现.
- KCS影响高达95%的SD患者,影响视力和生活质量.
- 它反映了SD中更广泛的免疫失调和上皮损伤.
研究的目的:
- 提供关于Sjögren病中KCS的全面更新.
- 审查SD中KCS的病变发生,诊断挑战和不断发展的治疗方法.
主要方法:
- 在SD中对KCS的病变发生,诊断和治疗方法的文献综述.
- 对自身免疫机制,免疫细胞参与和炎症途径的分析.
- 对诊断进展和治疗策略的评估.
主要成果:
- KCS的病理生理学涉及眼功能障碍,神经免疫相互作用和炎症.
- 异常免疫 (T/B细胞,细胞因子,IFN通路) 驱动眼睛表面损伤.
- 由于发现症状的差异,诊断是具有挑战性的;新的方法正在出现.
结论:
- KCS是SD的复杂表现,需要综合的诊断和治疗方法.
- 新兴的治疗方法侧重于免疫调节和再生,以恢复眼睛表面平衡.
- 需要进一步的研究来完善诊断和个性化治疗KCS在SD.
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