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Updated: Jan 16, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
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HDAC 抑制剂通过抑制 Hippo/YAP 信号通路来增强骨髓瘤细胞对 Etoposide 的化学敏感性

Zhijie Cao1, Yulu Chen1, Mengshan Chen1,2

  • 1National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

International journal of molecular sciences
|September 27, 2025
PubMed
概括

基因组脱乙酶抑制剂 (HDACis) 与埃托波 (VP16) 结合,通过增加细胞死亡和减少细胞增殖,增强骨髓瘤治疗. 这种组合针对Hippo/YAP通路,为抗化学抵抗性骨癌提供了潜在的策略.

关键词:
这是一种HDAC抑制剂.这是一种抗瘤药物.化学电阻是一种化学电阻.组合疗法治疗组合治疗.这里是etoposide的位置.骨质肉瘤是骨质肉瘤的一种疾病.

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