Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.8K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.8K
Drug Therapy01:28

Drug Therapy

245
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
245
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

693
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
693
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

474
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
474
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

817
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
817
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

607
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
607

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Physical and Mental Metaphors (PMM) task and its validation in schizophrenia: A tool for rapid assessment of figurative language comprehension, between pragmatics and symptoms.

Schizophrenia research. Cognition·2026
Same author

Psychological Interventions Targeting Auditory Hallucinations in Persons With Psychotic Disorders: A Systematic Review and Meta-Analysis.

JAMA psychiatry·2026
Same author

Social deprivation in schizophrenia spectrum disorders: A systematic review.

Journal of psychiatric research·2026
Same author

Transcranial Magnetic Stimulation for Bipolar Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials: Stimulation magnétique transcrânienne dans les cas de dépression bipolaire : une revue systématique et une méta-analyse d'essais contrôlés à répartition aléatoire.

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2026
Same author

Psychedelic-induced hypomania and mania: a systematic review and meta-analysis.

Molecular psychiatry·2026
Same author

Risk of all-cause and cause-specific mortality, and suicide attempt in people with anxiety and stress-related disorders: a systematic review, meta-analysis and meta-regression analysis of 165 studies.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026

相关实验视频

Updated: Jan 16, 2026

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
10:08

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

2.5K

微剂量迷幻药物用于恢复精神分裂症患者的突触密度.

Jacopo Sapienza1,2, Marco Spangaro1, Stefano Comai1,3,4,5

  • 1IRCCS San Raffaele Scientific Institute, 20127 Milan, Italy.

International journal of molecular sciences
|September 27, 2025
PubMed
概括

迷幻药可能有助于治疗精神分裂症,通过促进神经可塑性和突触生成,抵消突触损失. 在缺陷精神分裂症患者的初始试验中,建议使用微剂量.

关键词:
这是一种LSD,一种LSD.在SV2A中,它是SV2A.认知 认知 认知补充 4 补充 4 补充微质细胞中的微质细胞负面症状 负面症状神经可塑性 神经可塑性这种药物是psilocybin.精神错乱是一种精神病.这就是"synaptogenesis".

更多相关视频

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.4K
DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density
09:10

DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density

Published on: July 22, 2022

3.7K

相关实验视频

Last Updated: Jan 16, 2026

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
10:08

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

2.5K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.4K
DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density
09:10

DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density

Published on: July 22, 2022

3.7K

科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 遗传学 是一个遗传学.

背景情况:

  • 精神分裂症是一种多基因疾病,与突触平衡改变有关.
  • 补充成分4 (C4) 基因变异与精神分裂症有很强的关联,通过微质影响突触修剪.
  • 过度活跃的微质细胞和前额叶皮层 (PFC) 的突触密度降低是精神分裂症的标志.

研究的目的:

  • 探索迷幻药在治疗精神分裂症方面的潜力.
  • 调查迷幻药是否可以抵消突触损失并促进精神分裂症的神经可塑性.

主要方法:

  • 关于迷幻药对神经可塑性影响的临床前证据 (体外和动物模型) 的审查.
  • 考虑使用SV2A放射性对象进行体内研究,以评估精神分裂症患者的突触密度.

主要成果:

  • 临床前研究表明,迷幻药可促进神经可塑性和突触生成.
  • 通过SV2A成像证实,精神分裂症患者的PFC中的突触密度较低.
  • 迷幻药的潜力是恢复体积损失和改善负面/认知症状.

结论:

  • 迷幻药物通过增强突触连接显示出对精神分裂症治疗的希望.
  • 微剂量迷幻药物应首先在缺陷精神分裂症患者中探索.
  • 随着剂量变化的进一步研究可能会揭示更广泛的治疗应用.