编码热冲击蛋白的基因与严重COVID-19的风险和临床过程有关:试点研究
Andrey R Karpenko1,2, Ksenia A Kobzeva1, Yuriy L Orlov3,4
1Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
International journal of molecular sciences
|September 27, 2025
概括
人体热冲击蛋白 (HSP) 的遗传变异与严重的COVID-19风险有关. 特定的HSP基因变异影响疾病严重程度,影响男性,女性和吸烟者的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 病毒学 病毒学
背景情况:
- 人类热冲击蛋白 (HSP) 在病毒感染中表现出双重作用,可能保护或帮助病毒.
- 虽然在各种疾病中研究了HSP的作用,但它们在COVID-19进展中的具体参与尚未得到充分理解.
- 高血压患者的遗传变异可能会影响个人对COVID-19的易感性和严重程度.
研究的目的:
- 调查HSP的遗传变异及其调节器及其严重COVID-19风险之间的关联.
- 在与COVID-19严重程度相关的HSP基因中识别特定的单核酸多态 (SNP).
- 探索这些SNP对临床参数和疾病表现的影响.
主要方法:
- 在1228名受试者 (199名COVID-19患者,962名对照者) 中,对20个单核酸多态基因 (SNPs) 在HSP基因及其调节器中的基因定型.
- 统计分析以确定特定SNP与不同人口和生活方式群体的严重COVID-19风险之间的关联.
- 评估SNP对临床指标的影响,如地面玻璃不透明度,血液凝结和炎症标志物.
主要成果:
- 在DNAJA2 (T等位基因) 中SNP rs7189628与一般队列,男性和吸烟者的严重COVID-19风险增加有关.
- 在HSPA12B (C等位基因) 中SNP rs910652与一般队列,女性和正常身体活动的个体中严重的COVID-19风险降低有关.
- 在HSPA8 (A基因基因) 中SNP rs1136141与低水果/蔬菜摄入量患者的严重COVID-19风险增加相关. 此外,还发现各种HSPSNP与临床参数之间存在显著的关联.
结论:
- 初步证据表明,人类热冲击蛋白 (HSP) 基因中的特定遗传变异 (SNP) 可以显著调节COVID-19的风险和严重程度.
- 这些发现凸显了HSP遗传在确定个人COVID-19结果方面的潜在作用.
- 对分子机制的进一步研究是有必要的,以阐明所涉及的精确途径.
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