中性粒细胞在自身免疫性疾病和癌症中的作用
Anjali Bhargav1, Vinay Kumar2, Neeraj Kumar Rai3
1Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.
International journal of molecular sciences
|September 27, 2025
概括
中性粒细胞在疾病中起着双重作用,在慢性炎症,狼等自身免疫性疾病和癌症中起着保护性和破坏性作用. 向中性粒细胞功能为这些疾病提供了新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
背景情况:
- 中性粒细胞是关键的免疫细胞,在炎症,自身免疫和癌症中发挥着不同的作用.
- 微环境因素影响中性粒细胞的可塑性,影响它们的保护和致病功能.
- 失调的中性粒细胞子集,如自身免疫性疾病中的低密度粒细胞 (LDGs) 和癌症中的瘤相关中性粒细胞 (TAN),有助于疾病病理.
研究的目的:
- 探索中性粒细胞在慢性炎症,自身免疫性疾病和癌症中的多方面的作用.
- 突出中性粒细胞的功能可塑性和异质性.
- 讨论针对中性粒细胞功能的新兴治疗策略.
主要方法:
- 对炎症和瘤状况中中性粒细胞生物学现有文献的综述.
- 分析中性粒细胞子集 (LDGs,TANs) 和它们在疾病中的机制.
- 检查治疗策略,包括NET向和化学因子受体抑制.
主要成果:
- 中性粒细胞表现出取决于环境的作用,通过NETosis和I型干扰素信号传递,在自身免疫性疾病 (如SLE,RA,JIA) 中促进组织损伤.
- 与瘤相关的中性粒细胞 (TAN) 可以采用抗瘤 (N1) 或亲瘤 (N2) 表型,由TGF-β等因素调节.
- 新的治疗途径包括向中性粒细胞外细胞陷 (NETs),化学激素受体 (例如CXCR2) 和利用中性粒细胞生物标志物.
结论:
- 中性粒细胞是炎症和瘤疾病的关键参与者,表现出保护性和致病性能力.
- 了解中性粒细胞异质性和可塑性对于开发有效治疗方法至关重要.
- 向中性粒细胞是管理自身免疫病理和癌症进展的有希望的策略.
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