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泌尿癌中的新兴生物标志物:血管新生和与损伤相关的分子模式信号传递

Kacper Robert Karpiuk¹, Grzegorz Młynarczyk¹, Joanna Matowicka-Karna²

¹Department of Urology, Medical University of Białystok, 15-276 Białystok, Poland.

International journal of molecular sciences

|September 27, 2025

概括

本综述研究了六种关键生物标志物 (GDF15,VEGF,TGF-β1,HSP90,HMGB1,S100A9) 涉及泌尿癌. 多重生物标志物面板显示了改善早期检测和个性化治疗策略的前景.

科学领域:

尿瘤学尿瘤学
癌症生物标志物癌症生物标志物
瘤微环境瘤微环境

背景情况:

泌尿器官恶性瘤中的瘤-瘤相互作用涉及分泌和损伤相关的因素.
这些因素影响血管生成,免疫调节和转移.
六个关键生物标志物 (GDF15,VEGF,TGF-β1,HSP90,HMGB1,S100A9) 是这些过程的核心.

研究的目的:

综合当前关于6个特定生物标志物在泌尿癌中的生物功能和临床影响的证据.
分析这些生物标志物的诊断,预后和预测价值.
探索多重生物标志物面板在临床应用中的潜力.

主要方法:

文献综述综合了关于GDF15,VEGF,TGF-β1,HSP90,HMGB1和S100A9.9的证据.
在细胞癌和膀癌队列中对生物标志物的性能进行比较分析.
检查生物标志物在血管生成,免疫调节,转移和铁亡中的作用.

主要成果:

在细胞癌中,GDF15和HSP90与ferroptosis易感性相关.
尿路VEGF和HMGB1增加了对非侵入性膀癌的检测机会.
每个生物标志物在瘤进展和治疗反应中都表现出不同的作用.

结论:

多复合生物标志物面板有可能提高早期检测,风险分层和尿道瘤学个性化治疗.
需要前性研究来验证生物标志物值,相互作用和临床整合.
了解这些生物标志物对于推动泌尿癌管理至关重要.

关键词:

损伤相关分子模式 (DAMP) 是指损伤相关的分子模式.在GDF15中,GDF15是GDF15中的一个.这就是HMGB1的特点.在HSP90中,它是HSP90的.在S100A9A9中使用.在TGF-β1中.在VEGF中,VEGF是VEGF.血管新生是因为血管新生.膀癌:膀癌是一种癌症.细胞癌瘤是细胞癌.

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